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KMID : 0648620150200010007
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Korean Journal of Nosocomial Infection Control
2015 Volume.20 No. 1 p.7 ~ p.18
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Emergence and Spread of OXA-48-Like Carbapenemase-Producing Enterobacteriaceae
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Song Won-Keun
Jeong Seok-Hoon
Lee Jae-Cob
Lee Seung-Soon
Lee Kyung-Won
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Abstract
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Since 2001, ten more OXA-48 variants have been identified. Shewanella spp. has been thought to be the original host for OXA-48-like enzymes. These enzymes strongly hydrolyze penicillins and weakly hydrolyze carbapenems, with very weak activity against broad-spectrum cephalosporins. The OXA-48-like genes are always plasmid-borne and have been located in insertion sequences. OXA-48-like carbapenemases have been identified mainly from Turkey, North African countries, the Middle East, and India. Furthermore, the emergence and outbreak of OXA-48-like producers in Korea have been reported recently. Because some OXA-48-like-producing Enterobacteriaceae isolates do not exhibit resistance to broad-spectrum cephalosporins and only decreased susceptibility to carbapenems, their detection can be difficult. Adequate screening and detection methods are required to prevent and control the dissemination of OXA-48-like-producing Enterobacteriaceae.
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KEYWORD
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Class D carbapenemase, Enterobacteriaceae, OXA-48-like
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